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But alongside the impressive weight loss transformations, some patients are reporting something unexpected: emotional numbness

Continuous stimulation of GHRH receptors (as opposed to intermittent pulses) can cause receptor desensitization to occur

Seek urgent medical advice (contact your GP or NHS 111) if you experience: Severe or persistent abdominal pain, especially if accompanied by vomiting Persistent vomiting or inability to keep fluids down Signs of dehydration (extreme thirst, dark urine, dizziness) Sudden severe upper abdominal pain radiating to the back (possible pancreatitis) Severe right upper abdominal pain (possible gallstones) Severe bloating with vomiting and no passage of stool or gas (possible obstruction) Persistent or severe gastrointestinal symptoms may indicate the need for dose adjustment or, rarely, discontinuation of therapy

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However, the high cost of the medications offset the savings, the study authors said