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There is also evidence of the opposing phenomenon, therapeutic inertia, where there is a delay in intensifying treatment despite the availability of effective options

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However, response may vary: Higher baseline weight Individuals starting at higher body weights may experience: Slower percentage weight loss initially Need for full maintenance doses to achieve optimal effects Potentially better tolerance of higher doses Lower baseline weight Those with lower starting weights might: Achieve therapeutic goals at submaximal doses (e.g., 2.4 mg vs

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Thirdly, this study is its restriction to individuals of European ancestry