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Its a good choice for the gut health benefits this supplement is designed to impart, as a pair of randomized, double-blind, and placebo-controlled trials in 2019 found that a 10g daily dose of the stuff significantly improved stool frequency in a cohort at increased risk for constipation (ages 4075).29 Other studies, including a 2024 systematic review and meta-analysis, determined that chicory inulin may even help with weight management.30 The issue is that successful studies have used very high doses at least 10g per day, as opposed to the 276mg in Akkermansia so the chicorys role here appears to be exclusively as a food for the bacterial species

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If NAD+ is depleted, which caloric restriction can cause, the efficiency of these metabolic transitions suffers

At the 12 mg dose, nausea was reported by approximately 45% of participants

The first figure in the paper is the participant flow chart