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The future of therapeutic interventions for obesity may lie in developing strategies that selectively target specific GLP-1 receptor populations within the brain potentially minimising side effects while maximising their impact on appetite regulation and related behaviours such as food reward
Some researchers highlight this caution explicitly
When compared against the average risk score for a diabetic member, diabetic members not taking GLP-1s are riskier than average, while those taking GLP-1s were less risky than averageand, by a wider margin
J Neurochem 92(4):798806 Ambery P, Parker VE, Stumvoll M, Posch MG, Heise T, Plum-Moerschel L et al (2018) MEDI0382, a GLP-1 and glucagon receptor dual agonist, in obese or overweight patients with type 2 diabetes: a randomised, controlled, double-blind, ascending dose and phase 2a study
LH, lateral hypothalamus
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