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In direct trials, it notably outperformed injectable semaglutide (Ozempic)

Baseline muscle mass, pre-existing nutritional deficiencies, and concurrent medical conditions such as diabetes or inflammatory diseases can also affect muscle preservation during semaglutide therapy

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For example, the SURMOUNT-1 trial showed average weight loss of up to 20.9% with tirzepatide, while the STEP 1 trial for semaglutide showed an average loss of around 14.9%, demonstrating tirzepatide's higher efficacy