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For EPA/DHA, in addition to involvement in these pathways, studies report anti-inflammatory actions via increased pro-resolving oxylipins, along with reduced mitochondrial ROS, up-regulation of UCP2, and SIRT1PGC-1-dependent mitochondrial biogenesis
Glutathione is well-tolerated by most
Patients should seek urgent medical attention if they experience severe persistent abdominal pain (which may indicate pancreatitis), persistent vomiting/dehydration, jaundice, acute visual changes, or hypoglycaemia if on insulin or sulfonylureas
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