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In the initial larger, higher resolution, dataset of Cagri-CTR-Gs ( N = 1), density was observed for the proximal region of the conjugated lipid at the peptide N-terminus that was consistent regardless of peptide conformation (bypass or CT-like) and supports modelling the Glu linker and a short segment of acyl chain in a different orientation to that observed in the AMY 1 R complex (Figs

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This result is consistent with previous studies that reported cardiac succinate accumulation during ischemia 53 , but is the first demonstration of ischemic succinate in the pericardial fluid

For instance, a novel ratiometric fluorescent probe based on monochlorinated boron dipyrromethene (BODIPY) derivatives has been reported recently by Yang et al