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These conjugates are formed from small-molecule therapeutics with reactive functional groups forming covalent protein adducts in vivo, which can trigger anti-drug antibody (ADA) responses, include hypersensitivity and allergy reactions
doi: 10.1038/nri3322 114 ShiYMuL
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doi: 10.1002/iid3.1074 112 Mercimek-MahmutogluSPatelJCordeiroDHewsonSCallenDDonnerEJet al
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