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Anthracyclines such as doxorubicin and epirubicin cause cell death and cytotoxicity by intercalating into DNA and disrupting replication, this is part of standard treatment (67, 215)
Other context-specific reasons are governing decisions to [not] manufacture via recombinant expression (e.g., existing infrastructure / expertise [though both Eli Lilly and Novo Nordisk recombinantly express insulin])
Whereas a few initial studies suggested beneficial effects by treatment with synbiotics [252],[253], one trial reported increased mortality in the verum group [254]
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The injectable formulation is manufactured in multiple dose strengths to allow for stepwise titration: 0.25 mg once weekly for 4 weeks 0.5 mg once weekly for 4 weeks 1 mg once weekly for 4 weeks 1.7 mg once weekly for 4 weeks Maintenance dose: 2.4 mg once weekly The oral tablet is only available in a single 25 mg strength offering a fixed-dose daily regimen
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US$ 29.71
