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Since cardiovascular complications of diabetes (62, 63) as well as diabetic nephropathy (64) are associated with an imbalance in the activity of RAAS, the interaction with this system could explain some of the beneficial effects of GLP1-RA
Gastrointestinal burden Retatrutide already produces significant GI side effects
Helps reduce oxidative stress and retinal damage
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Moore prefers starting with conservative approaches oral options when available and tailoring the choice to the clinical target
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