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Gene expression analyses further show upregulation of antioxidant-response elements, reinforcing mechanistic consistency at both biochemical and transcriptional levels
Additionally, SIRT3 deacetylates ceramide synthases, promoting ceramide accumulation and inhibiting complex III activity 184
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36 Thus it appears that the mechanism of action of POL and STS is to produce endothelial damage, 37 but not thrombus formation associated with platelet aggregation
Diabetes Care (2011) 34(Suppl 2):S2517.10.2337/dc11-s227 38 ZhongJMaiseyeuADavisSNRajagopalanS
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