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The accelerated healing in burns of treated mice includes the activity of the pentadecapeptide BPC 157 (Figure 1), given locally (as a cream) or systemically (ip), on the inflammatory cells, edema, reticulin, collagen, necrosis, blood vessel formation, number of preserved follicles, re-epithelization, tensile breaking strength, and water content in burned skin
After numerous manipulations on candidate molecules, one was arrived at that acted as a non-peptide GLP-1 agonist and was given the name orforglipron. Now came the next challenge
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