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Pre-clinical work across skin, lung, liver, and bone models has reported tissue-repair activity, attributed to fibroblast restoration, antioxidant signaling, anti-inflammatory effects, and matrix-protein synthesis
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Research in rodent models has consistently demonstrated that supplement with 25(OH)D3 leads to increased expression of NGF and BDNF in central nervous system tissues, highlighting the potential neurotrophic effects of VD metabolites [101]
PMC 201508
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