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These glycosylphosphatidylinositol-anchored receptors bind folic acid with nanomolar affinity and rapidly internalize the vitamin along with any attached cargo through clathrin-mediated endocytosis, delivering the entire construct directly into acidic endosomal compartments where pH-sensitive linkages can trigger drug release [7, 128]

Could this signal peripheral nerve effects that might extend to cardiac autonomic nerves

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