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This trial involved participants who had obesity or overweight along with at least one weight-related health issue (excluding type 2 diabetes), who were given a 2.4 mg dose of semaglutide
Preclinical studies have demonstrated that FGF21 could enhance AMP-activated protein kinase (AMPK) signaling, favoring fatty acid oxidation and reducing de novo lipogenesis, which contributes to suppression of fibrosis and improvement of metabolic status 20
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