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Approved Uses: Ozempic is primarily prescribed for managing type 2 diabetes but also has weight loss benefits
The exact mechanisms, particularly the role of cannabinoid signaling, need more exploration
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As a potent acylated peptide, BI 456906 incorporates a C18 fatty acid to prolong its half-life and maintains stability against DPP-4 proteolytic degradation through C-terminal amidation and substitution at the second amino acid [109]
The American Diabetes Association (ADA) and American College of Cardiology (ACC) now recommend GLP-1 receptor agonists with proven cardiovascular benefit, including semaglutide, as preferred agents for patients with diabetes and atherosclerotic cardiovascular disease
