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Acknowledgements This project was completed by the Laboratory of Thoracic Surgery, The First Affiliated Hospital of Soochow University
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Advanced molecular studies reveal that FOXO4-DRI promotes p53 nuclear exclusion and subsequent mitochondrial targeting, where p53 interacts with BCL-2 family proteins to promote mitochondrial outer membrane permeabilization and cytochrome c release
(21) regarding the correlation between hyperinsulinemia and hyperandrogenism, to the foundational work by Dunaif and Nestler (19801990) that established the causal relationship between IR and PCOS (23, 24), and through to the debates on the universality of this axis following the formulation of the Rotterdam diagnostic criteria (2003) (25, 26)
Compounded versions are not part of our prescribing practice due to their uncertain efficacy and safety
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