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Both L-carnitine loss into the dialysate and impaired synthesis by the kidneys contribute to a progressive carnitine deficiency in patients with end-stage renal disease (ESRD) undergoing hemodialysis (71)

Reassurance and simple interventions, such as relaxation exercises, drinking water, and addressing any reflux, are often helpful

Mild symptoms may improve, but severe or persistent nausea deserves clinical review

The anti-apoptotic and anti-inflammatory effects of IRR activation may reduce tubular cell death and interstitial inflammation the pathological processes that drive progressive kidney damage

This question comes up constantly, and the honest answer depends on individual factors