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After inspection of the apo-OsDHAR structure, we predicted that the highly conserved Cys20 residue acts as the catalytic nucleophile and found that this residue is located at the cleft between the N- and C-terminal subdomains
Kenneth Custer, executive vice president and president of Lilly Cardiometabolic Health, said in a statement last year announcing the trial results
Boronic ester linkage Among the various ROS-cleavable linkers, arylboronic ester is unique owing to its high selectivity towards H 2 O 2
Synthesis of the 2,2-(propane-2,2-diylbis(sulfanediyl))bis(ethan-1-ol) The 2,2-(propane-2,2-diylbis(sulfanediyl))bis(ethan-1-ol) was synthetized using a similar procedure as previously reported 48
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