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In addition, adipose tissue secretes proinflammatory cytokines, including tumor necrosis factor- (TNF-) and interleukin-6 (IL-6), which may impair neuromuscular control and exacerbate nocturnal respiratory instability (9, 10)

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Subsequent differentiation to M2 macrophages, under the influence of liraglutide treatment, also proved the anti-atherosclerotic effect of GLP-1 receptor agonist since M2 macrophages have been numerously identified in murine atherosclerosis regression models