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The study identifies the indolizino[1,2-b]quinolinone scaffold as a promising framework for dual PDE1B/PDE10A inhibition
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Clinical data is lacking
The primer sequences used and the sizes of caspase-3 and glial fibrillary acidic protein (GFAP) housekeeping -actin are shown in Table 1
Briefly, cells (5 10 8 ) cultured on 15-cm dishes were rinsed twice with ice-cold PBS and immediately incubated with 2 ml of homogenized buffer on ice and harvested using a cell scraper
The concern regarding PQQ and glutathione depletion stems primarily from specific laboratory studies
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