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Why clinical guidance remains essential Although medications such as semaglutide, tirzepatide and, potentially in the future, retatrutide can be highly effective, they work best as part of a structured weight management programme
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Start low and climb slowly
If your doctor wants to prescribe you GLP-1s, youll need to have some blood work done to verify that youre healthy enough for the drugs and to identify any potential contraindications that would make you a better candidate for one or another
Mendelian randomization studies have identified a causal relationship between increased body mass index (BMI) and heightened kidney disease risk, with each standard deviation increase in BMI nearly doubling disease probability (odds ratio: 2.00) (155)
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