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In recent years, different studies on CKD patients and animal models, such as mice, demonstrated that eryptosis, triggered by factors such as uremic toxins, inflammation, oxidative stress, and imbalances in calcium homeostasis, plays a fundamental role in the development and progression of renal anemia
Acta 187 , 614 (2020)
These free radicals can be extremely malignant as they break apart molecules such as DNA and proteins, and ultimately lead to cell membranes getting damaged which can trigger and lead to the development of cancer
Vimentin treatment increased transcription of GLUT1 and hypoxia-inducible factor 1 (Hif-1) but decreased GLUT4 transcription
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