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Multiple studies have established that the hypothalamus serves as the central integrative hub for satiety and appetite regulation
This section is particularly important for men with athletic builds, people who have lost substantial weight on their semaglutide program , and anyone with a BMI under 25 who is using semaglutide for blood sugar management rather than weight loss
Tirzepatide works as a dual agonist, meaning it activates two specific receptors
Additionally, tirzepatide did not attenuate the reduction of sleeping metabolic rate or 24-h sedentary energy expenditure in comparison to baseline (though not significantly different than placebo), but significantly increased fat oxidation and decreased carbohydrate and protein oxidation as compared to placebo [57]
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