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Combining tirzepatide with GLP-1 and GIP hormones may lead to a more significant reduction in inflammation compared to GLP1RAs alone due to their anti-inflammatory effects [58]
Melanie Haines (Mass General) identified advanced age, female sex, and low protein intake as the biggest predictors of muscle loss
For perspective, older obesity drugs only saw a 5% drop
The researchers speculated that the increased lean body mass was due to more efficient muscle protein synthesis from the less-degraded l-citrulline in the bloodstream
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