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2-adrenoceptor agonists Clonidine gel: A randomized, double-blind, placebo-controlled, parallel-group, multicenter trial showed that topical clonidine gel significantly reduced the level of pain in subjects with DN in whom there are functional (and possibly sensitized) nociceptors in the affected skin
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Consequently, despite the potential for higher initial blood levels, the inherent physiological immaturity and reduced somatic mass associated with preterm birth mean that these infants have significantly diminished endogenous L-carnitine reserves
An intramuscular injection would lead to a much faster, more aggressive absorption spike, which isn't the goal here
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