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J Neurosci (2017) 37:124056
The pattern of results, particularly the amplification of benefit at higher weight loss thresholds, is consistent with the hypothesis that HRT restores a metabolic environment that makes GLP-1 therapy more effective: improving insulin sensitivity, preserving lean mass, reducing the inflammatory burden that blunts metabolic responsiveness, and supporting the mitochondrial function that underlies energy regulation
Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease
Enzymes in the bloodstream chew it up in a matter of minutes
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