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The clinical research currently consists of the following: Small 1980s pilot trials No large modern RCTs Limited pharmacokinetic clarity No validated subcutaneous dosing protocol for improved sleep DSIP likely works for many individuals, but its critical to acknowledge the doses used by the biohacking community comes from extrapolation
Several factors support this conclusion
They demonstrated that pretreatment of cultured SOD1 G93A astrocytes with MitoQ was able to reduce the formation of superoxide and peroxynitrite radicals, protect motor neurons against oxidative damage and improve the ability of mitochondria to generate ATP (Cassina et al., G93A mouse model, treatment with MitoQ at the onset of disease also delayed the decline of mitochondrial function in the spinal cord, protected against motor neuron loss and astrogliosis in the spinal cord
Hu, Z.-J
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