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Endocrinology 152, 46104619
Like GLP-1 receptor agonists, tirzepatide also has an FDA-mandated black box warning for patients with a personal or family history of medullary thyroid cancer and those who have multiple endocrine neoplasia syndrome type 2
(28) GLP-1 users had a lower all-cause mortality rate (18.3 per 10,000 person-years) compared to DPP4-Is (69.9 per 10,000 person-years) and older agents (52.5 per 10,000 person-years)
Iuculano, A., et al
Outsourcing facilities should confirm whether any GLP-1 compounding relies on bulk substances, reassess whether any product is identical or nearly identical to an approved drug and document the basis for continuing any formulation in light of FDA's express statement that semaglutide and tirzepatide are not on the 503B bulks list or drug shortage list
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