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The route of administration for gut indications differs from musculoskeletal use
Groups at increased risk of B12 deficiency include: Vegans and strict vegetarians , who avoid all animal products and are at significant risk without supplementation or fortified foods Older adults , in whom reduced stomach acid production impairs B12 absorption People with pernicious anaemia , an autoimmune condition that destroys intrinsic factor-producing cells Those who have undergone gastric surgery , including bariatric procedures, which can reduce intrinsic factor availability Individuals taking long-term metformin for type 2 diabetes, as this medication is associated with reduced B12 absorption the MHRA has issued specific safety advice on monitoring B12 levels in this group [6] [7] People with conditions affecting the small intestine , such as Crohn's disease or coeliac disease Symptoms of B12 deficiency can include fatigue, weakness, pins and needles, memory difficulties, and a sore or inflamed tongue (glossitis)
Standard cycle: 46 weeks Extended cycle with monitoring: up to 12 weeks for complex or chronic presentations Rest period between cycles: 48 weeks is typical Duration matters because tissue remodeling continues for weeks after a cycle ends
Semaglutides trade-offs are cost, gastrointestinal side effects, contraindications including medullary thyroid carcinoma history, and the need for careful titration
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