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[21] [22] [23] [24] Starting in 2007, health agencies in various countries began issuing warnings against their use
GLP-1 (glucagon-like peptide-1) is a natural hormone released in the gut after eating that helps regulate appetite and blood sugar levels
Cancer Res 13 , 15231532 (2015)
Early Metabolic Shifts: Lower fasting blood sugar, improved insulin sensitivity
HbA1c lowering effect The results of the clinical trials demonstrated significantly greater reductions in A1C with liraglutide compared to exenatide, and both GLP-1 receptor agonists caused greater reductions than those observed with sitagliptin [7] Data regarding these four agents from published head-to-head studies suggest that Liraglutide may have the largest A1C lowering capability, followed by dulaglutide, exenatide once weekly and then exenatide twice daily ( Figure 5 ) [8-10] GLP-1 RA are associated with an A1c reduction of 0.5-1.5% which is greater than 0.5-1% from DPP4 inhibitors the in head to head Duration clinical trials [11]
