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Medications such as metformin [Glucophage], phentermine [Adipex-P], topiramate [Topamax], bupropion [Wellbutrin], and naltrexone [Revia] (sometimes used alone or in combination, [such as Contrave]) can be effective and are often available as inexpensive generics, sometimes for as little as $10 to $20 per month

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Muscle protein is one source

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It works by enhancing insulin secretion, which slows gastric emptying, leading to decreased appetite and weight loss

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Resistance to chemotherapy and radiotherapy is both intrinsic and acquired: the blood-brain barrier makes delivery of chemotherapeutic drugs to neoplastic cells difficult, and GBM itself is molecularly heterogeneous and often features robust DNA repair mechanisms such as enhanced methylated-DNA-protein-cysteine methyltransferase (MGMT) activity (14 This review examines the metabolic landscape of GBM, with a focus on the widespread reprogramming of energy pathways that enables tumor cells to adapt and thrive in harsh microenvironments

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Seven additional TRIUMPH Phase 3 readouts in obesity, type 2 diabetes, OSA, NASH, cardiovascular outcomes, and chronic low back pain are expected during 2026

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