Medications such as metformin [Glucophage], phentermine [Adipex-P], topiramate [Topamax], bupropion [Wellbutrin], and naltrexone [Revia] (sometimes used alone or in combination, [such as Contrave]) can be effective and are often available as inexpensive generics, sometimes for as little as $10 to $20 per month
Muscle protein is one source
It works by enhancing insulin secretion, which slows gastric emptying, leading to decreased appetite and weight loss
Resistance to chemotherapy and radiotherapy is both intrinsic and acquired: the blood-brain barrier makes delivery of chemotherapeutic drugs to neoplastic cells difficult, and GBM itself is molecularly heterogeneous and often features robust DNA repair mechanisms such as enhanced methylated-DNA-protein-cysteine methyltransferase (MGMT) activity (14 This review examines the metabolic landscape of GBM, with a focus on the widespread reprogramming of energy pathways that enables tumor cells to adapt and thrive in harsh microenvironments
Seven additional TRIUMPH Phase 3 readouts in obesity, type 2 diabetes, OSA, NASH, cardiovascular outcomes, and chronic low back pain are expected during 2026