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Pre-infusion CAR T cells of long-term responders (LTR) have increased oxidative phosphorylation, fatty acid oxidation, and pentose phosphate pathway activities, higher mitochondrial mass, tighter cristae, and lower mTOR expression compared to products of short-term responders

Health Canada requires generic medications to be pharmaceutically equivalent to brand-name drugs, meaning they must contain the same active ingredient in the same strength and dosage form

Most side effects are dose-related and manageable, especially with gradual titration

Rats averaged 802 86 g at baseline with equivalent variances between the groups

Furthermore, it is likely that the optimal ratio of receptor agonism across target receptors varies between individuals