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Studies have found that the longer cellular damage is allowed to occur, the more cellular function is impaired, giving way to the accumulation of even more damaged cells and accelerated aging
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However, owing to their limited anticancer activity or drug toxicity, a number of clinical trials targeting IGF-1R have been abandoned and few drugs have actually entered clinical use
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Acknowledgements This work was partially supported by the Finish Line grant of Markey Cancer Center to H.S.Y as well as the Biostatistics and Bioinformatics, Biospecimen Procurement and Translational Pathology, and Flow Cytometry and Immune Monitoring Shared Resource facilities of the University of Kentucky Markey Cancer Center (P30CA177558)
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