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Many anticonvulsant drugs act by increasing GABA in the synapse.[ref] Genetic variants that decrease the function of the GABA-A receptors essentially decreasing GABA inhibition are linked to an increased risk of epileptic seizures.[ref] Insomnia: Brain GABA levels were studied in people with primary insomnia who were not on medication

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In mice, the benefits of FOXO4-DRI continued to develop after the treatment period ended, as tissue remodeling and functional recovery are ongoing processes (Baar et al., 2017)