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Enter glutathione, universally recognized in the medical community as the "master intracellular antioxidant." While healthy bodies naturally synthesize enough of this vital compound to neutralize daily metabolic waste, the immense inflammatory burden of complex chronic illnesses can overwhelm these built-in systems
Abbreviations BBC: Boston Birth Cohort BMC: Boston Medical Center CpG: 5-Cytosine-phosphate-guanine-3 CYP2E1: Cytochrome p450 family 2 subfamily e member 1 CV: Coefficient of variation DNA: Deoxyribonucleic acid DNAm: DNA methylation DNMT3A: DNA methyltransferase 3 alpha DNMT3B: DNA methyltransferase 3 beta ENCODE: Encyclopedia of DNA elements EWAS: Epigenome-wide association study FDR: False discovery rate GSH: Glutathione HELLP: Hemolysis, elevated liver enzymes and low platelets SD: Standard deviation LC-MS: Liquid chromatography-tandem mass spectrometry NAPQI: N -acetyl- p -benzoquinone imine SVA: Surrogate variable analysis TET1: Ten-eleven translocation methylcytosine dioxygenase 1 References Werler MM, Mitchell AA, Hernandez-Diaz S, Honein MA
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Traditional drug discovery often focuses on a single target, but AI makes it feasible to identify multiple therapeutic targets simultaneously
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