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Although PARP-1 is the primary enzyme involved in DNA repair, PARP-2 also plays an important role, and its activity can likewise contribute to the depletion of cellular NAD levels (Gu et al., 2019)
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A 2023 meta-analysis of 11 clinical trials found that GLP1 RAs significantly improved natural pregnancy rates and menstrual regularity in women with PCOS - while also reducing insulin resistance, testosterone levels, and BMI [Source: BMC Endocrine Disorders, 2023] When insulin resistance and excess weight are brought under control, hormonal balance often follows
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