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Cardiovascular disease is the main cause of mortality in individuals with MASLD, who face a two- to threefold greater risk of both fatal and non-fatal cardiovascular events than the general population [14]
This leads to multiple future therapeutically relevant opportunities: Obesity Treatment : Modulating SPTBN1 expression or function could provide a novel therapeutic strategy to combat obesity by inhibiting the Caspase-3SPTBN1 axis and its downstream effects
In addition, a selective GIP agonist showed very low effectiveness in reducing weight, while this co-agonist showed synergism in reducing fat mass in obese rodents
1.3 kg/m 2 [1.4]
Brain abbreviations are as follows: NAc, nucleus accumbens
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