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The rodent findings may not directly translate to human risk due to significant species differences in thyroid C-cell biology and GLP-1 receptor expression
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Front Endocrinol 13:1046130 Inia JA, Stokman G, Morrison MC, Worms N, Verschuren L, Caspers MPM, Menke AL, Petitjean L, Chen L, Petitjean M, Jukema JW, Princen HMG, van den Hoek AM (2023) Semaglutide Has Beneficial Effects on Non-Alcoholic Steatohepatitis in Ldlr-/-.Leiden Mice
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Moreover, a large-scale randomized controlled trial (RCTs) involving more than 17,000 individuals with obesity and cardiovascular disease demonstrated that semaglutide reduced the risk of cardiovascular death, myocardial infarction (MI), and stroke compared to the placebo 9
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