glp-1 medications nutrient deficiency effects Nutritional priorities to support therapy for obesity: a joint Advisory from the American College of Lifestyle Medicine, the American Society for Nutrition, the Obesity Medicine Association, and The Obesity Society GLP-1 receptor agonists and next-generation

J Pharm Sci 102(6):17121723 Schmid I, Bonnington L, Gerl M, Bomans K, Thaller AL, Wagner K et al

Brand-name only: Wegovy, Zepbound, Saxenda

426 In contrast to AI/ML approaches that derive statistical correlations from data, mechanistic modeling builds mathematical representations based on underlying biological processes to explain and predict drug resistance

For example, the deletion of HDAC9 in mouse CD4 + T cells increases histone H3 lysine 9 acetylation (H3K9ac) and H3K18ac at the PPAR- promoter, promoting a shift in T cell cytokine production toward a more anti-inflammatory profile while reducing the production of anti-dsDNA autoantibodies by B cells

7073 Woo et al