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Some treatments that would eventually become widely embraced, such as hormone replacement therapy for menopause, started in the backwater of compounding pharmacies
NNMT is an enzyme that methylates nicotinamide, a key NAD+ precursor, depleting cellular methyl donor pools and influencing both NAD+ availability and broader methylation pathways
Some reports point to possible involvement in pathways connected to fat storage and cellular size, although these findings remain limited to experimental settings
The mechanism behind the possible influence of B12 on the circadian rhythm is not clear, but there is evidence to suggest that B12 may increase the light sensitivity of the circadian clock
When assessing for vitamin B12 deficiency, in addition to checking a vitamin B12 level, consider ordering a methylmalonic acid level or a holotranscobalamin level and CBC (to assess for red blood cell size)
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