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Case 2 dropped 26.8% of body weight in 39 weeks while gaining 1.2 kg of LST

5 KEY APPROACHES TO OVERCOME CHALLENGES IN PEPTIDE DELIVERY Protein engineering to resist enzymatic degradation Enzyme inhibitors and stabilizers for protection and stability PEGylation and albumin binding for half-life extension Enteric coatings for pH protection Encapsulation systems (eg, nanoparticles, liposomes) Permeation enhancers like SNAC Mucoadhesive systems for prolonged mucosal contact Several of these approaches are achieved by use of appropriate excipients

[13] [12] Individual response varies considerably based on baseline microbiome composition, diet, medications, and health status

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10.3390/ijms20092313 13 AnwarH