It has been investigated as a treatment for growth hormone deficiency and lipodystrophy, reaching phase II clinical trials that were discontinued for reasons unrelated to administration of the peptide
In contrast, a pooled analysis of clinical trials reporting separate CV events rates in patients with T2D and CKD did not find GLP1-RA to be associated with a reduction in composite CV event rates [76]
The FDA confirmed the 2008 market withdrawal of Geref was not due to safety or efficacy concerns
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