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The Formula Concentration (mg/mL) = Total semaglutide in vial (mg) Diluent added (mL) Units to draw = (Prescribed dose in mg Vial strength in mg) Diluent (mL) 100 Illustrative Example (formula demonstration only not a dosing recommendation) Suppose a vial is labeled as containing 5mg of semaglutide, and it has been reconstituted with 2mL of diluent per the product's specific reconstitution instructions

Population-level posterior predictions were generated at prespecified dose pairs, holding treatment duration constant at a representative value to ensure comparability across treatments

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