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Subsequently, 3-hydroxy-methylglutaryl-CoA lyase (HMGCL) cleaves HMG-CoA in an irreversible reaction into acetyl-CoA and the first ketone body, AcAc
In participants with overweight/obesity without diabetes, the highest dose of retatrutide produced 24.2% reduction in body weight after 48 weeks [75]
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Many patients experience modest weight loss while taking it, though it is not officially approved for obesity treatment
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