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Intravenous (IV) glutathione is limited by an extremely short half-life in the plasma, and it cannot cross cell membranes intact, but must be broken down and resynthesized within the cell

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Glp-1 receptor agonists and diabetic kidney disease: a call of attention to nephrologists

IV delivery does achieve higher peak plasma concentrations a bolus IV push puts a large quantity of glutathione into circulation at once