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Dose optimization is complicated by the distinct tissue distribution and enzymatic kinetics of PDE1B and PDE10A, potentially impacting the therapeutic index and adverse effect profiles

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Br J Pharmacol (2014) 171(10):255267.10.1111/bph.12512 26 MalhotraR

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A blend requires verification of each component individually before combination

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Factors such as temperature, pH, oxygen, light, and metal ions can significantly accelerate this oxidation process

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03 What you may notice: Skin elasticity and firmness continue improving

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