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Once a vial has been punctured and is in use, it is generally recommended to discard any leftover solution after ~28 days for sterility reasons (even if within the chemical BUD)

If there is persistent foam that does not resolve after five minutes, you likely shook the vial too aggressively

Summary: Making Your Choice As we continue through 2026, the data is clear: Use morning dosing if you need to be active, reduce stiffness, and manage daytime pain

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