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Diagnost (Basel)

doi:10.1210/jcem.81.1.8550773 van Bloemendaal L, IJzerman RG, Ten Kulve JS, et al

For comprehensive anti-aging goals, sermorelin is often considered the primary choice because: It aligns with natural hormone rhythms and sleep-based GH release It has a longer clinical history and prior FDA-approved status It supports sustained pituitary function over time Sleep improvement is typically rapid and pronounced However, ipamorelin offers advantages when anti-aging goals are focused on body composition, recovery, and maintaining a clean hormonal profile

Both aerobic exercise and resistance training stimulate GLP-1 release

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