These enzymes are the pyruvate dehydrogenase complex (PDHc) and 2-oxoglutarate (-ketoglutarate) dehydrogenase (OGDH), both of which are associated with the TCA cycle, and branched-chain ketoacid dehydrogenase (BCKD) necessary for metabolism of the branched-chain amino acids, leucine, isoleucine, and valine
Diarrhea: Less common and typically intermittent, potentially due to dietary changes or the effect of semaglutide on the gastrointestinal tract lining
Unknown peptides
Patients often notice they can comfortably adhere to smaller portions, avoid excessive snacking, and make healthier choices without feeling deprived
Most information comes from patient forums and social media, where reports are mixed: some describe renewed appetite suppression on re-start, while others report weight gain during breaks and significant nausea on resuming previous doses, often requiring a full re-titration